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Rechkoblit O,* Gupta YK,* Malik R,* Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK. (2016) Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Science Advances, Oct 21;2: e1601317.
*Co-first author

Divakar S, Vasquez R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mullholland D, Guha C, Aggarwal AK, Reddy EP. (2016) A small molecule RAS-mimetic disrupts RAS association with effector proteins to block signaling. Cell, Apr 21;165(3):643-655.*
*
Highlighted in Nature Reviews Cancer  2016, 16, 342-343, Cancer Discovery 2016, June 2 (6), 573

Callahan SJ, Luyten YA, Gupta YK, Morgan RD, Wilson GG, Roberts RJ, Aggarwal AK. (2016) Crystal structure of type IIL restriction-modification enzyme MmeI in complex with DNA: implications for engineering of new specificities. PLoS Biology, Apr 15;14(4):e1002442.

Gupta YK, Chan SH, Xu SY, Aggarwal AK. (2015) Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nature Communications, Jun 6:7363.

Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S. (2015) An inhibitor of PIDDosome formation. Mol Cell, Jun 4;58(5): 767-79.

He X, Hull V, Gidwani S, Fu X, Gupta YK, Thomas JA, Black LW, Xu SY. (2015) Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference. Sci. Rep., May 19;5:9747.

Chen X, Ali Khajeh J, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJE, Bu Z. (2015) Phospatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assmebles a specific CD44-Ezrin hetero complex, as revealed by small angle neutron scattering. J. Biol. Chem., Mar 6;290(10):6639-52.

Stachnik A, Yuen T, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, (13 authors), Buettner C, Bian Z, Zallone A, Aggarwal AK, Haider S, New M, Sun L, Narla G, Zaidi M. (2014) Repurposing of bisphosphonates for the prevention and therapy of non-small cell lung cancer. Proc Natl Acad Sci USA, Dec 16; 111:17995-18000.

Yuen T, Stachnik A, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, (12 authors), Davies T, Bian Z, Zallone A, Aggarwal AK, Haider S, New M, Sun L, Narla G, Zaidi M. (2014) Bisphosphonates inactivate human EGFRs to exert anti-tumor actions. Proc Natl Acad Sci USA, Dec16; 111:17989-17994.

Mujtaba S, Winer BY, Jaganathan A, Patel J, Sgobba M, Schuch R, Gupta YK, Haider S, Wang R, Fischetti VA. (2013) Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages. J. Biol. Chem., Aug 9;288(32):23458-72.

Xu SY, Gupta YK. (2013) Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res., Jan 1;41(1):378-90.

Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK. (2012) Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small angle x-ray scattering. J. Mol Biol., Jul ;420(4-5):261-8.

Xu SY, Nugent RL, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, Wang X, Li Z, Zheng Y, Morgan R. (2012) Characterization of Type II and III restriction-modification systems from Bacillus cereus strains ATCC10987 and ATCC14579. J. Bacteriol., Jan;194(1):49-60.

Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK. (2009) Co-occupancy of two Pumilio molecules on a single hunchback NRE. RNA, Jun;15:1029-35.

Gupta YK, Nair DT, Wharton RP, Aggarwal AK. (2008) Structures of human pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure, Apr;16, 549-557.*
*Featured on journal’s cover, RNA Apr 2009: 15 (4)

Bertini, I, Gupta, YK, Luchinat C, Parigi G, Peana M, Sgheri L, Yuan J. (2007) Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains. J. Am. Chem. Soc., Oct 24;129(42):12786-12794.

Edwards, TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer III AG, Aggarwal AK. (2006) Solution structure of the Vts1 SAM domain in the presence of RNA. J. Mol. Biol., Mar 10;356(5):1065-72.

Bertini I, Gupta YK, Luchinat C, Parigi G, Schlörb C, Schwalbe H. (2005) NMR Spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz. Angew. Chem. Int. Ed., Apr 8;44 (15), 2223-5.

Baig I, Bertini I, Del Bianco C, Gupta YK, Lee YM, Luchinat C, Quattrone A. (2004) Paramagnetism-based refinement strategy for the solution structure of human α-Parvalbumin. Biochemistry, May 11;43 (18), 5562–73.

Meeting abstracts:

Oussenko IA, Gupta YK, Vasquez R, Reddy R, Aggarwal AK, Reddy EP, Holland JF, Ohnuma T. Structure-function analysis of RPL18A, a putative binding target of rigosertib. Cancer Res  2015 August 1; 75;694. (presented at AACR 2015)